Find Hope When Depression Feels Overwhelming
A research study for people living with bipolar depression in Stone Mountain. Up to $1,500 compensation and free round‑trip Uber to every visit.
About theBipolar Depression Study
Our PI wants to personally reach out to you so that you are aware of this study.
We would love to welcome you in and explore what options might be a good fit.
You’re Not Alone in This
About the Study
At our Stone Mountain research center, Dr. Maria E. Johnson and her team are studying a new treatment that may help lift the weight of bipolar depression. We’re looking for people who feel stuck in the fog of depression despite trying other treatment options.
Compensation & Transport
You’ll receive up to $1,500 total compensation for completing study visits. We also provide free round‑trip Uber transportation to all visits so you don’t need to drive or arrange a ride.
Who We’re Looking For
Adults 18–74 with bipolar I or II currently in a depressive episode lasting at least 4 weeks, especially if joy feels distant and motivation is hard. If you’re ready to try something different, we’d love to talk.
Could This Study Help You?
We’re Looking for People Who:
- Have bipolar I or bipolar II disorder
- Are currently in a depressive episode (lasting at least 4 weeks)
- Feel like nothing brings pleasure anymore (anhedonia)
- Are between 18–74 years old
- Want to try something different
You Know the Feeling:
- Exhaustion that sleep doesn’t fix
- Emptiness where excitement used to be
- Effort it takes just to shower or make a meal
- Disconnect from people you love
- Frustration with treatments that haven’t worked well enough
This study is specifically designed to target these symptoms.
What Makes This Different
A research approach focused on bipolar depression symptoms like loss of pleasure and motivation
A Novel Approach to Bipolar Depression
About the Study Medication
Azetukalner is an investigational medication with a unique mechanism. Instead of targeting serotonin, it works on potassium channels in the brain that help neurons communicate. This approach is designed to address anhedonia — the loss of pleasure — and other core symptoms of bipolar depression.
Why This Matters
Many existing options can take weeks to help and may not address numbness and loss of pleasure. Earlier studies of azetukalner suggested meaningful improvements at the 20 mg dose being studied here. This trial focuses exclusively on bipolar I and II depression.
Different From Typical Antidepressants
Azetukalner works on potassium channels (tiny switches for brain-cell signaling), not serotonin.
Mechanism aims to reduce risk of triggering mania.
Targets Anhedonia
Addresses the numbness and emptiness where nothing feels enjoyable.
Participants reported music, food, and time with loved ones feeling meaningful again.
Close Monitoring & Safety
Generally well‑tolerated; the most common effects reported were mild dizziness and drowsiness that often improved.
You’ll have regular safety check‑ins.
Potential for Faster Relief
In earlier studies, some people improved within one week (not 4–6 weeks).
Individual results vary; this is still investigational.
About Dr. Maria E. Johnson
Principal Investigator
Dr. Johnson has spent 15 years caring for people with bipolar disorder and leading mood disorder research. “I’ve seen how bipolar depression can steal so much from people’s lives,” she says. “We’re committed to Find treatments that work faster and better.”
Board Certified
Psychiatry
Mood Disorder Expert
15 years of bipolar care and research
Faster Relief Focus
Committed to treatments that work sooner
“No one should have to wait months to feel relief from bipolar depression. That’s why we’re studying treatments that may help sooner.”
Everything We Provide
Financial, transportation, and medical support designed to make participation easier during depression.
Up to $1,500 Compensation
Payments are provided after each visit for your time and commitment. You are compensated whether you receive study medication or placebo.
Free Uber Transportation
Round-trip Ubers to every visit. No driving, no parking, no asking for rides. We handle arrangements.
All Care Provided at No Cost
Study medication, psychiatric evaluations, regular health monitoring, labs, EKGs, and ophthalmology exams — no insurance required.
Compassionate Psychiatric Care
Experienced mood disorder team providing careful monitoring and support throughout screening, treatment, and follow‑up.
What to Expect
From screening to follow‑up, we’ll support you every step. Free Uber provided for all visits.
Screening Visits (2–4 weeks)
We’ll discuss your history and current symptoms, do health checks (blood work, EKG), and ensure the study is safe for you. Free Uber provided.
Treatment Phase (6 weeks)
Take one capsule daily with dinner. You’ll have regular visits to see how you’re doing and talk about symptoms. Uber picks you up and brings you home.
Follow‑up Phase (8 weeks)
We’ll check in to make sure you’re okay, see if improvements continue, and discuss possible longer‑term options. Transportation always included.
Flexible Scheduling & Support
Our team schedules appointments around your needs and provides compassionate support. Many participants find the structure and care helpful during depression.
Frequently Asked Questions
Find answers to common questions about our clinical research study.
Have more questions about the study?
Get Help TodaySchedule Your Free Evaluation
Find out if you're a good fit for this investigational study. Our team will contact you within 24 hours.
Why Schedule Today?
Voluntary Participation
We can only accept a limited number of participants for this investigational study.
No-Cost Evaluation
Your consultation and all study-related care is provided at no cost to qualified participants.
No Obligation
The consultation is informational only - you decide if this investigational study is right for you.
Take the First Step Today
Call or text +1 (404) 999‑2734. Or email info@denali-health.com. We provide the Uber — you don’t need to worry about getting here.
Office Location
Address
5329 Memorial Drive STE A
Stone Mountain, GA 30083
Hours
Mon–Fri: 8am–5pm
Sat: 9am–1pm (by appt)
Transportation
Free Uber provided
Free parking if preferred
Book Online
If You're in Crisis Right Now
If you're having thoughts of suicide or self-harm, please reach out for help immediately:
- Crisis Lifeline: Call or text 988
- Emergency: Call 911
- Crisis Text Line: Text HOME to 741741
You matter. Your life matters. Help is available right now.